Carl-Henrik Heldin Selected Research

Becaplermin (PDGF-BB)

1/2022	Deubiquitinating enzymes USP4 and USP17 finetune the trafficking of PDGFRβ and affect PDGF-BB-induced STAT3 signalling.
1/2020	Erratum: Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression: Erratum.
1/2020	Specific targeting of PDGFRβ in the stroma inhibits growth and angiogenesis in tumors with high PDGF-BB expression.
1/2018	PDGFRβ translocates to the nucleus and regulates chromatin remodeling via TATA element-modifying factor 1.
5/2013	The Fer tyrosine kinase is important for platelet-derived growth factor-BB-induced signal transducer and activator of transcription 3 (STAT3) protein phosphorylation, colony formation in soft agar, and tumor growth in vivo.
3/2012	MKP3 negatively modulates PDGF-induced Akt and Erk5 phosphorylation as well as chemotaxis.
2/2011	Combination therapy using imatinib and vatalanib improves the therapeutic efficiency of paclitaxel towards a mouse melanoma tumor.
12/2007	Identification of a subset of pericytes that respond to combination therapy targeting PDGF and VEGF signaling.
12/2007	Platelet-derived growth factor receptor-beta, carrying the activating mutation D849N, accelerates the establishment of B16 melanoma.
4/2004	Platelet-derived growth factor production by B16 melanoma cells leads to increased pericyte abundance in tumors and an associated increase in tumor growth rate.

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Carl-Henrik Heldin Research Topics

Disease

69	Neoplasms (Cancer) 10/2023 - 08/2002
15	Breast Neoplasms (Breast Cancer) 01/2023 - 03/2005
12	Prostatic Neoplasms (Prostate Cancer) 08/2022 - 02/2003
9	Carcinoma (Carcinomatosis) 01/2018 - 03/2002
7	Neoplasm Metastasis (Metastasis) 01/2022 - 07/2006
5	Carcinogenesis 01/2022 - 01/2010
3	Hypoxia (Hypoxemia) 07/2022 - 02/2010
3	Glioblastoma (Glioblastoma Multiforme) 01/2022 - 01/2018
3	Hyperplasia 01/2022 - 03/2004
3	Glioma (Gliomas) 01/2022 - 09/2006
3	Experimental Melanoma 01/2020 - 04/2004
3	Inflammation (Inflammations) 10/2019 - 08/2002
3	Triple Negative Breast Neoplasms 10/2018 - 04/2017
3	Melanoma (Melanoma, Malignant) 02/2011 - 12/2007
2	Osteosarcoma (Osteogenic Sarcoma) 04/2023 - 01/2022
2	Lung Neoplasms (Lung Cancer) 03/2021 - 01/2016
2	Virus Diseases (Viral Diseases) 01/2020 - 10/2019
2	Pulmonary Arterial Hypertension 01/2020 - 11/2019
2	Neurodegenerative Diseases (Neurodegenerative Disease) 01/2015 - 03/2008
2	Gastrointestinal Stromal Tumors (Gastrointestinal Stromal Tumor) 01/2007 - 10/2004
2	Atherosclerosis 12/2006 - 01/2004
2	Neointima 12/2006 - 03/2004
1	Lymphoma (Lymphomas) 04/2023
1	Mitochondrial Diseases (Mitochondrial Disease) 01/2022
1	Ovarian Neoplasms (Ovarian Cancer) 11/2021
1	Endometrial Neoplasms (Endometrial Cancer) 07/2021
1	type 2 Hemochromatosis 01/2020
1	Lewis Lung Carcinoma 01/2020
1	Circulating Neoplastic Cells 01/2020
1	Hereditary Hemorrhagic Telangiectasia 01/2020
1	Vascular Diseases (Vascular Disease) 11/2019
1	Fever (Fevers) 10/2019
1	Infections 10/2019
1	Dengue (Dengue Fever) 10/2019
1	Severe Dengue 10/2019
1	Liver Neoplasms (Liver Cancer) 05/2019
1	Hepatocellular Carcinoma (Hepatoma) 05/2019

Drug/Important Bio-Agent (IBA)

19	Proteins (Proteins, Gene)FDA Link 10/2023 - 08/2002
16	Transforming Growth Factors (Transforming Growth Factor)IBA 10/2023 - 07/2012
15	Transforming Growth Factor beta (TGF-beta)IBA 03/2021 - 03/2002
12	Platelet-Derived Growth Factor Receptors (Platelet-Derived Growth Factor Receptor)IBA 04/2023 - 10/2002
11	Transcription Factors (Transcription Factor)IBA 11/2019 - 07/2006
10	Becaplermin (PDGF-BB)FDA Link 01/2022 - 04/2004
10	Phosphotransferases (Kinase)IBA 01/2022 - 12/2006
8	Platelet-Derived Growth FactorIBA 01/2022 - 10/2002
7	TNF Receptor-Associated Factor 6 (TRAF6)IBA 08/2022 - 02/2009
7	Messenger RNA (mRNA)IBA 01/2022 - 08/2002
7	Imatinib Mesylate (Gleevec)FDA Link 01/2020 - 09/2003
6	UbiquitinIBA 04/2023 - 06/2005
6	Ligases (Synthetase)IBA 04/2023 - 06/2005
6	Bone Morphogenetic Proteins (Bone Morphogenetic Protein)IBA 11/2021 - 08/2002
5	Hyaluronic Acid (Hyaluronan)IBA 11/2022 - 01/2019
5	CytokinesIBA 01/2022 - 10/2008
5	Platelet-Derived Growth Factor beta Receptor (Receptor, Platelet Derived Growth Factor beta)IBA 01/2015 - 10/2002
4	Biomarkers (Surrogate Marker)IBA 01/2022 - 10/2007
3	RNA (Ribonucleic Acid)IBA 10/2023 - 11/2021
3	LigandsIBA 04/2023 - 08/2002
3	Intercellular Signaling Peptides and Proteins (Growth Factors)IBA 01/2022 - 10/2007
3	Epidermal Growth Factor (EGF)IBA 01/2020 - 01/2016
3	ErbB Receptors (EGF Receptor)IBA 01/2020 - 03/2011
3	Protein Isoforms (Isoforms)IBA 01/2020 - 05/2012
3	p38 Mitogen-Activated Protein KinasesIBA 01/2014 - 02/2003
2	ChromatinIBA 10/2023 - 01/2019
2	Smad Proteins (Mothers Against Decapentaplegic Homolog)IBA 10/2023 - 08/2002
2	Fibronectins (Fibronectin)IBA 11/2022 - 05/2019
2	Hyaluronan SynthasesIBA 07/2022 - 01/2019
2	Protein Kinases (Protein Kinase)IBA 01/2022 - 01/2016
2	NestinIBA 01/2022 - 10/2021
2	TNF Receptor-Associated Factor 4IBA 03/2021 - 09/2013
2	Proto-Oncogene Proteins c-sis (Platelet Derived Growth Factor B)IBA 01/2020 - 01/2015
2	EndoglinIBA 01/2020 - 02/2010
2	CollagenIBA 11/2019 - 01/2017
2	Tyrosine Kinase InhibitorsIBA 12/2018 - 02/2011
2	CarcinogensIBA 01/2018 - 01/2015
2	Presenilin-1IBA 01/2015 - 01/2014
2	Vascular Endothelial Growth Factor Receptors (VEGF Receptors)IBA 02/2011 - 12/2009
2	Paclitaxel (Taxol)FDA LinkGeneric 02/2011 - 10/2002
2	vatalanib (PTK787)IBA 02/2011 - 12/2007
2	Activin Receptors (Activin Receptor)IBA 01/2010 - 08/2002
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 12/2009 - 03/2008
2	Platelet-Derived Growth Factor alpha ReceptorIBA 01/2007 - 10/2004
2	Transforming Growth Factor beta1 (TGF beta 1)IBA 02/2003 - 03/2002
1	Long Noncoding RNAIBA 10/2023
1	Ubiquitin-Protein Ligases (Ubiquitin-Protein Ligase)IBA 04/2023
1	Hyaluronoglucosaminidase (Hyaluronidase)FDA Link 11/2022
1	Aurora Kinase BIBA 08/2022
1	Peptide Hydrolases (Proteases)FDA Link 08/2022
1	Adenosine Triphosphate (ATP)IBA 01/2022
1	Red Fluorescent ProteinIBA 01/2022
1	DNA Methyltransferase 3AIBA 01/2022
1	Phenobarbital (Luminal)FDA Link 01/2022
1	Lipid Bilayers (Lipid Bilayer)IBA 01/2022
1	Cadherins (E-Cadherin)IBA 01/2022
1	Fibroblast Growth Factors (Fibroblast Growth Factor)IBA 11/2021
1	Reactive Oxygen Species (Oxygen Radicals)IBA 10/2021
1	Tumor Necrosis Factor Receptors (Tumor Necrosis Factor Receptor)IBA 03/2021
1	Cytostatic AgentsIBA 01/2021

Therapy/Procedure

11	Therapeutics 01/2020 - 10/2004
3	Drug Therapy (Chemotherapy) 02/2011 - 10/2002
1	Castration 08/2022